EMILIN-1 (Elastin Microfibril Interface Located Protein 1): Structural Support, Cellular Signalling, and Implications in Cardiovascular Health
Endocrinology Diagnostics
Basic Structure and Role
- Glycoprotein essential for extracellular matrix formation
- Present in elastic tissues like blood vessels and skin
- Contains C-terminal region and EMI domain
- Helps maintain tissue structural integrity and elasticity
Extracellular Matrix Functions
- Organizes microfibers that anchor elastin
- Maintains flexibility in frequently stretched tissues
- Helps tissues withstand mechanical strain
- Bridges structural support with cellular activities
Cardiovascular Impact
- Regulates blood pressure levels
- Inhibits TGF-β pathway to prevent fibrosis
- Maintains blood vessel elasticity
- Deficiency linked to increased atherosclerosis risk
Cellular Signaling Role
- Interacts with integrin α4β1 for cell attachment
- Regulates inflammation responses
- Controls cell migration and adhesion
- Helps protect against tissue damage
Therapeutic Potential
- Target for treating fibrotic conditions
- Could help prevent blood vessel stiffening
- Shows promise for inflammatory disease treatment
- Research ongoing for molecule development
- Potential applications in cardiovascular and respiratory diseases
Suitable ELISA Kits
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